Chemical biology across the University of Oxford

Monday 10th November 2014
09:00 - 17:20
Saïd Business School
twitter logo #OxCBH

A symposium by ChemBio Hub to strengthen interdepartmental research connections

If you want to discuss the symposium or ideas you’ve had since... Get in touch

Symposium Overview

Speakers from eight Oxford departments explored a diverse range of topics, with a particular focus on interdepartmental collaboration in small molecule drug discovery.

Attendees found out more about who works on what, and where - as well as meeting new colleagues from across the University and exploring ideas for new research connections.

Contacts

Michael
O'Hagan


Email Michael

Karen
Porter


Email Karen

To see tweets about the symposium, search for hashtag...

#OxCBH

Themes

Centres of chemical biology research at Oxford

Centres of chemical biology research at Oxford

The impact of chemistry on biology and medicine

The impact of chemistry on biology and medicine

Small molecules in therapeutic discovery

Small molecules in therapeutic discovery

Interdepartmental collaboration in chemical biology

Interdepartmental collaboration in chemical biology

This event was generously supported by:

Department of Chemistry
John Fell OUP Research Fund
Cancer Research UK
Oxford Cancer Research Centre

Symposium Summary

What did our attendees get out of this symposium?

7

New collaboration ideas

11

New research connections or contacts

18

Improved awareness of research in other departments

We have blogged about the symposium...

On 10th November 2014 the ChemBio Hub team held a cross-departmental symposium at the Saïd Business School in the centre of Oxford. Attendees from a broad range of departments in the chemical and biological sciences met to hear about cutting-edge research projects happening across the University. This started lots of useful conversations that generated ideas for new research collaborations. [more]

At our recent Chemical Biology in Oxford symposium, we conducted a lightning survey to find out more about what people wanted from ChemBio Hub. [more]

18

attendees agreed this type of event should be run more regularly

Here are some event suggestions from the day...

"More detail on the different compound libraries size/ throughput/ cost/ applications"

"Antibacterial drug discovery: overcoming resistance. Phenotypic screens/ target-based screens for antibacterial drug candidates"

"Diseases associated with mutations that impair fold but do not abrogate function. This way I will meet the authors contributing to the above database."

"Nucleic acid cell visualisation techniques"

"...specific molecule themes (eg demethylases, methyl transferases)"

Here's what people thought about the symposium...

"The packed programme had excellent speakers and gave our students the opportunity to network and see how some other cross-collaborative projects, such as ours, work successfully"

Dr Tracey MarrOxIOSCR programme, Department of Chemistry

"We reached the maximum number of registrations within a few days, then had 96 attendees in a 100 seat venue. Add to that the overwhelmingly positive feedback we received on the day. These all point to a great appetite within the University for researchers to get together to share their expertise. We have heard that message and will be working hard to provide the right opportunities to meet the need."

Karen PorterChemBio Hub

"Many thanks - I thought the day was very good"

Prof Chris SchofieldDept of Chemistry

"The talks I attended gave a good overview of what is going on in the University."

PIDept of Biochemistry

"I now have a better understanding of the drug discovery research in place in Oxford"

PIDept of Physiology, Anatomy & Genetics

"It was a great day on the whole and the crowd turn up was really good. I also liked the posters [and not to forget the food!]"

Octovia MonteiroTarget Discovery Institute

"I have better ideas of who has what expertise and how this may be synergistic with my own research"

PostdocDept of Chemistry

"I had a great day at the ChemBioHub symposium – really useful. Many thanks."

PIWIMM

19

are interested in using our ChemBio Crunch utility to improve their workflow

ChemBio Crunch screenshot
Crunch being demoed by Andrew
ChemBio Crunch screenshot

"[I would use Crunch for] Analysis of physicochemical properties for drug development"

Tharindi PanduwawalaDept of Chemistry

"I need a database of disease-associated mutations in secreted protein, with patients in Oxford and info from assays on the same protein..."

Pietro RoversiDept of Biochemistry

"I would like ways to compare novel protein targets to drug databases as an initial computer-based screening method"

Tom MilneWetherall Institute

Symposium attendees

Click an attendee name to see their personal profile page.
Hover over the information symbol to see their brief biography.

Martin
Cohn

Biochemistry

Mark
Howarth

Biochemistry

Robert
Gilbert

STRUBI

Chris
Norbury

Pathology

Grant
Churchill

Pharmacology

David
Vaux

Pathology

Christina
Redfield

Biochemistry

Peter
O'Neill

Oncology

Ester
Hammond

Oncology

Sridhar
Vasudevan

Pharmacology

Michael
Willis

Chemistry

Holger
Kramer

DPAG

Peter
McHugh

Oncology

Katja
Simon

WIMM

Mike
Stratford

Oncology

Sangeeta
Aditya

Chemistry

Khalid
Al-Qahtani

Chemistry

Roberta
Baronio

Target Discovery Institute

Paul
Barrett

ChemBio Hub

James
Bennett

Target Discovery Institute

Andrew
Bowen

Isis Innovation

Anthony
Bradley

SGC

Tom
Brown

Oncology

Julia
Busch

Biochemistry

Samuel
Cahill

Chemistry

Rebecca
Carter

Oncology

Rod
Chalk

SGC

James
Crowe

SGC

Melissa
D'Ascenzio

Target Discovery Institute

Luigi
De Collibus

STRUBI

Sara
De Omellas

Chemistry

Grigory
Dianov

Oncology

Peter
Dobson

Engineering Science

Daniel
Ebner

Target Discovery Institute

Jonathan
Elegheert

STRUBI

Oleg
Fedorov

Target Discovery Institute

Lisa
Folkes

Oncology

Thomas
Folliard

Biochemistry

Matteo
Gianella-Borradori

Chemistry

Thorsten
Hauler

Physiology, Anatomy and Genetics

Geoff
Higgins

Oncology

Richard
Hopkinson

Chemistry

Marie W
Johannsen

Chemistry

Laia
Josa Culleré

Chemistry

Alastair
Kerr

Physiology, Anatomy and Genetics

Benedikt
Kessler

Target Discovery Institute

Stefan
Knapp

Target Discovery Institute

Wen Hwa
Lee

SGC

Michele
Lufino

DPAG

James
McCullagh

Chemistry

Michaael
McDonough

Chemistry

Joanna
McGouran

Chemistry

Tom
Milne

WIMM

Octovia
Monteiro

WIMM

Kenny
Moore

Sir William Dunn School of Pathology

Keith
Moyse

Biochemistry

Shubhash
Mukhopadhyay

SGC

Michael
O'Hagan

ChemBio Hub

Ray
Owens

STRUBI

Tharindi
Panduwawala

Chemistry

Radhika
Patel

Biochemistry

Hayden
Peacock

Chemistry

Dan
Pinkas

SGC

Karen
Porter

ChemBio Hub

Carolyn
Porter

Isis Innovation

Kathryn
Pugh

Target Discovery Institute

Jieqiong
Qiu

Chemistry

Xioamei
Ren

Chemistry

Pamela
Reynolds

Oncology

Pietro
Roversi

Biochemistry

Schaefer
Phillipp

Chemistry

Schofield
Chris

Chemistry

Giuseppe
Scozzafava

Target Discovery Institute

Lea
Sefer

Biochemistry

Andrew
Stretton

ChemBio Hub

Sam
Thompson

Chemistry

Agnes
Tyburn

Chemistry

Quin
Wills

Wellcome Trust Centre for Human Genetics

Graham
Wynne

Chemistry

Toru
Yamashita

Chemistry

Sheng
Yu

Oncology

Nicole
Zitzmann

Biochemistry

Slides

Brian Marsden

Chemical Biology across The University

Chris Schofield

Chemical Biology – starting points for discussion

Karen Porter

The ChemBio Hub project - supporting world class chemical biology research

Paul Brennan

Chemical probes for epigenetic proteins

Tom Brown

Extending the boundaries of nucleic acid chemistry

Graham Wynne

Small Molecule Utrophin Modulators: Towards a Therapy for Duchenne Muscular Dystrophy

More slides from the symposium presentations will be available shortly - check back soon

Posters

In vitro Screening Platforms for the Discovery of Novel Epigenetic Probes

In vitro Screening Platforms for the Discovery of Novel Epigenetic Probes

James Bennett

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OOMMPPAA: A tool to aid directed synthesis using activity and structural data

OOMMPPAA: A tool to aid directed synthesis using activity and structural data

Anthony Bradley

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Direct detection of DNA Methylation at CpA units

Direct detection of DNA Methylation at CpA units

Marie Johannsen

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Tetramates as Anticancer and Antibacterial core scaffolds

Tetramates as Anticancer and Antibacterial core scaffolds

Laia Josa Culleré

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Investigating changes in TCA cycle metabolism associated with isocitrate dehydrogenase (IDH) mutations in brain tumours

Investigating changes in TCA cycle metabolism associated with isocitrate dehydrogenase (IDH) mutations in brain tumours

James McCullagh

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A Chemoproteomic Assay for the Analysis of Bromodomain Inhibitors

A Chemoproteomic Assay for the Analysis of Bromodomain Inhibitors

Kathryn Pugh

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Biomolecular Solution-state NMR in the Department of Chemistry

Biomolecular Solution-state NMR in the Department of Chemistry

Christina Redfield

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Highly Efficient Enzymatic Fluorescent Labelling of DNA Probes

Highly Efficient Enzymatic Fluorescent Labelling of DNA Probes

Xiaomei Ren

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ESR12 Rapid access to anticancer natural products and diverse derivatives

ESR12 Rapid access to anticancer natural products and diverse derivatives

Philipp Schäfer

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Bioanalysis Core Facility – HPLC and flow cytometry

Bioanalysis Core Facility – HPLC and flow cytometry

Mike Stratford

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Target Discovery Institute

Target Discovery Institute

Dan Ebner

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Establishing a National Phenotypic Screening Capability in the UK

Establishing a National Phenotypic Screening Capability in the UK

Dan Ebner

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Programme

09:00
Registration and coffee
09:30
Welcome – Dr Brian Marsden (PI Research Informatics, SGC, Kennedy Institute, ChemBio Hub)
09:40
SESSION 1: CENTRES OF CHEMICAL BIOLOGY RESEARCH AT OXFORD
Chair: Dr Richard Wade-Martins (DPAG)
09:40-10:00
Professor Chris Schofield (Chemistry)
The Department of Chemistry
10:00-10:20
Professor Chas Bountra (SGC)
The SGC
10:20-10:40
Daniel Ebner (Target Discovery Institute)
‘Cell-based phenotypic screening at the Target Discovery Institute and the UK National Phenotypic Screening Centre’
10:45
Coffee & Posters
11:15
SESSION 2: THE IMPACT OF CHEMISTRY ON BIOLOGY AND MEDICINE
Chair: Dr Grant Churchill (Pharmacology)
11:15-11:40
Dr Stuart Conway (Chemistry)
‘Hypoxia-activated prodrugs’
11:40-12:05
Dr Paul Brennan (SGC)
‘Chemical probes for epigenetic proteins’
12:05-12:30
Professor Tom Brown (Chemistry)
‘Extending the boundaries of nucleic acid chemistry’
12:30
Lunch & Posters
13:40
SESSION 3: SMALL MOLECULES IN THERAPEUTIC DISCOVERY
Chair: Dr Paul Brennan (SGC)
13:40-14:00
Karen Porter (Project manager, ChemBio Hub)
‘The ChemBio Hub project: supporting world class chemical biology research’
14:00-14:25
Dr Geoff Higgins (Oncology)
‘Identification of drug targets to increase tumour radio sensitivity’
14:25-14:50
Dr Richard Wade-Martins (DPAG)
‘Identifying novel small molecule therapeutics by cell phenotype screening: three short stories from brain and heart’
14:50-15:15
Professor Nicole Zitzmann (Biochemistry)
‘Iminosugars as antivirals’
15:20
Coffee & Posters
15:50
SESSION 4: INTERDEPARTMENTAL COLLABORATION IN CHEMICAL BIOLOGY
Chair: Professor Stefan Knapp (Target Discovery Institute)
15:50-16:15
Dr Graham Wynne (Chemistry)
‘Drug screening for Duchenne Muscular Dystrophy’
16:15-16:40
Dr Susanne Müller-Knapp (SGC) and Dr Tom Milne (WIMM)
‘A chemical probe for the chromatin remodeller BAZ2B and its potential application’
16:40-17:05
Dr Benedikt Kessler (Target Discovery Institute) and Dr Grigory Dianov (Oncology)
‘Chemical probes and applications in the ubiquitin system’
17:10
Closing remarks - Professor Chas Bountra (Chief Scientist, SGC)